The Relationship between Plasma Taurine Levels and Diabetic Complications in Patients with Type 2 Diabetes Mellitus

The Relationship between Plasma Taurine Levels and Diabetic Complications in Patients with Type 2 Diabetes Mellitus

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Background: Taurine has an active role in providing glucose homeostasis and diabetes causes a decline in taurine levels.This paper investigates the relationship between taurine and diabetic complications, patients’ demographic features, and biochemical parameters.Methods: Fifty-nine patients PRO VISION with type 2 diabetes mellitus (T2DM), and 28 healthy control subjects between the ages of 32 and 82 were included in the study.The mean age of subjects was 55.

6 ± 10.3 and mean diabetes duration was 10.2 ± 6.0 years.

The most commonly accompanying comorbidity was hypertension (HT) (64.5%, n = 38), and the most frequent diabetic complication was neuropathy (50.8%, n = 30).Plasma taurine concentrations were measured by an enzyme-linked immunoassay (ELISA) kit.

Results: Plasma taurine concentrations were significantly lower in diabetic patients (0.6 ± 0.1 mmol/L) than controls (0.8 ± 0.

2 mmol/L) and in hypertensive (0.6 ± 0.1 mmol/L) patients (p = 0.000, p = 0.

027 respectively).Conclusion: Plasma taurine levels were decreased in patients with T2DM and this was not related to FBG, HbA1c, and microalbuminuria.With regard to complications, we only found a correlation with neuropathy.We suggest that taurine levels may be more Bathroom important in the development of diabetes; however, it may also have importance for the progression of the disease and the subsequent complications.

We further assert that taurine measurement at different times may highlight whether there is a causal relationship in the development of complications.